Thursday, November 24, 2011

Egyptian court orders release of 3 US students

FILE - In this Tuesday, Nov. 22, 2011 file image from Egyptian state television, three American students are displayed to the camera by Egyptian authorities following their arrest during protests in Cairo, where an Egyptian official said they were throwing firebombs at security forces. A spokeswoman for the American University in Cairo identified the students as Luke Gates, a 21-year-old Indiana University student from Bloomington, Ind.; Derrik Sweeney, a 19-year-old Georgetown University student from Jefferson City, Mo.; and Gregory Porter, a 19 year-old Drexel University student from Glenside, Pa. An official says an Egyptian court has ordered release of 3 US students arrested during Cairo unrest.(AP Photo/ Egyptian TV, File)

FILE - In this Tuesday, Nov. 22, 2011 file image from Egyptian state television, three American students are displayed to the camera by Egyptian authorities following their arrest during protests in Cairo, where an Egyptian official said they were throwing firebombs at security forces. A spokeswoman for the American University in Cairo identified the students as Luke Gates, a 21-year-old Indiana University student from Bloomington, Ind.; Derrik Sweeney, a 19-year-old Georgetown University student from Jefferson City, Mo.; and Gregory Porter, a 19 year-old Drexel University student from Glenside, Pa. An official says an Egyptian court has ordered release of 3 US students arrested during Cairo unrest.(AP Photo/ Egyptian TV, File)

(AP) ? Egyptian officials say a court has ordered the release of three American students arrested this week during the unrest in Cairo.

An Egyptian official said Thursday the three who attend the American University in Cairo were arrested on the roof of a university building near Cairo's iconic Tahrir Square where they were allegedly throwing firebombs at security forces fighting with protesters.

The three, arrested Sunday, are Derrik Sweeney, a 19-year-old Georgetown University student, Luke Gates, a 21-year-old Indiana University student, and Gregory Porter, a 19-year-old Drexel University student.

The officials spoke on condition of anonymity because they were not authorized to speak to the media.

THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.

CAIRO (AP) ? Egyptian officials say a court has ordered the release of three American students arrested this week during the unrest in Cairo.

An Egyptian official said Thursday the three who attend the American University in Cairo were arrested on the roof of a university building near Cairo's iconic Tahrir Square where they were allegedly throwing firebombs at security forces fighting with protesters.

The three, arrested Sunday, are Derrik Sweeney, a 19-year-old Georgetown University student, Luke Gates, a 21-year-old Indiana University student, and Gregory Porter, a 19-year-old Drexel University student.

The officials spoke on condition of anonymity because they were not authorized to speak to the media.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-11-24-Egypt-American-Students/id-3c9f5d04885242e6a53e1405d73848fa

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'Idol' producer: No major changes for new season (AP)

NEW YORK ? "American Idol" executive producer Nigel Lythgoe (NY'-juhl LIHTH'-goh) says don't expect any major changes when the hit Fox TV show returns in January.

Lythgoe returned as "Idol's" executive producer last season to usher in the post-Simon Cowell era with new judges Steven Tyler and Jennifer Lopez and a new mentor for contestants, veteran music producer Jimmy Iovine. He says all of them are back for the new season.

Lythgoe says he's "not sure" the show wants to make too many more tweaks this year.

Lythgoe says the most significant change introduced last year was to allow the contestants to sing in their own styles rather than force them to perform styles unsuited for them. He says that opened the door for last season's winner, teenage country singer Scotty McCreery.

____

Online:

http://www.americanidol.com

Source: http://us.rd.yahoo.com/dailynews/rss/tv/*http%3A//news.yahoo.com/s/ap/20111123/ap_en_tv/us_tv_american_idol

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Wednesday, November 23, 2011

Poor recycling of BACE1 enzyme could promote Alzheimer's disease

Monday, November 21, 2011

Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology (www.jcb.org).

Abeta, the toxic protein that accumulates in the brains of Alzheimer's patients, is formed when enzymes cut up its parental protein, known as amyloid precursor protein. One of those enzymes is beta-secretase or BACE1. BACE1 cycles between the Golgi apparatus and the plasma membrane, traveling through endosomes on the way. A protein complex called the retromer helps transport proteins back from endosomes to the Golgi. Previous studies have found reduced levels of two retromer components, including the protein VPS35, in the brains of patients with Alzheimer's disease.

To find out whether VPS35 affects Alzheimer's disease progression, Wen-Cheng Xiong and colleagues crossed two mouse lines to create animals that are prone to many symptoms of the disease and generate half the normal amount of VPS35. The mice displayed Alzheimer's-like abnormalities earlier than their parental strains, and their brains accumulated more Abeta.

Cells lacking VPS35 carried extra BACE1 in their endosomes, consistent with a defect in retromer-mediated protein transport. BACE1 is more active in the acidic interior of endosomes than in the more basic surroundings of the Golgi apparatus. Thus, by leaving more BACE1 trapped in endosomes, the decline in VPS35 levels could enhance BACE1 activity and generate more Abeta. Although no VPS35 mutations have so far turned up in Alzheimer's patients, the protein's level in the brain dwindles in aging mice. The researchers suspect that certain Alzheimer's disease risk factors, such as oxidative stress, also diminish VPS35 levels in the brain.

###

Rockefeller University Press: http://www.rupress.org/

Thanks to Rockefeller University Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/115359/Poor_recycling_of_BACE__enzyme_could_promote_Alzheimer_s_disease_

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Gray reassigns communications director | Liz Farmer | Capital Land ...

D.C. Mayor Vincent Gray announced his new communications director on Monday while admitting his administration has struggled to effectively get out his message to the public during its first 11 months.

He also named his new deputy chief of staff after the previous one served for less than two weeks then resigned after it was revealed she illegally voted in the District.

Gray's former communications director, Linda Wharton-Boyd, has been reassigned to the D.C. Department of Health.

"There?s an awful lot going on and yes, there are days when I feel like the message hasn?t gotten out there as much as we would like [it] to," Gray said at a news conference. However, he added that the media has also done more than a fair share, he thought, of negative reporting.

Replacing Boyd is Pedro Ribiero, the communications director and deputy chief of staff to Rep. Zoe Lofgren, D-Calif. Sheila Bunn, the former chief of staff to D.C. Del. Eleanor Holmes Norton, was named as Gray's deputy chief of staff.

Gray's chief of staff, Chris Murphy, acknowledged that the speed at which Gray's message has reached reporters and the public has been lacking. He said Ribiero and Bunn's experience on Capital Hill would help fix that.

"The pace ? as everyone in this room knows ? of media has changed," Murphy said. "I think Pedro and Sheila have experienced that first-hand and that kind of speedy reaction will help us get out the mayor's agenda. ... In the communications realm, I think the Hill is used to that 24-hour news cycle."

Source: http://washingtonexaminer.com/blogs/capital-land/2011/11/gray-reassigns-communications-director

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Addressing Fashion's Communications Conundrum ? BoF ? The ...

Victoria's Secret Fashion Show 2011 | Source: Victoria's Secret

NEW?YORK, United States ??In recent years, the main fashion weeks in New York, London, Milan and Paris have attracted unprecedented interest from end consumers, with brands live streaming their shows and bloggers reporting from the runway in realtime on their sites and social channels like Twitter and Instagram. But in most cases, the actual clothes showcased during fashion week aren?t available to consumers until many months after the shows have finished.

In short, fashion?s communication cycle has become wildly out of sync with its retail cycle. Would the film industry ever hold a movie premiere 6 months ahead of its release to the public? Would Apple make its buzzy product announcements a half-year before said products were available for sale?

By shortening lead times, planning production in advance, and using other?lean manufacturing techniques, fashion brands may be able to get product to consumers more quickly. But these kinds of structural changes could take years to implement, especially as many fashion brands do not control the means of production.

One solution has been to let consumers order ? but not receive ? products immediately after the shows. Mega-brands like Burberry have offered pre-ordering for several seasons now, while a number of mid-sized and emerging brands have collaborated with ?pre-tail? trunk-show start-up?Moda Operandi to do the same. But market reports suggest that the sales volume of pre-orders has been limited. There are only so many consumers who are willing to plonk down money in advance to guarantee they will get a specific garment in their size months later. Most consumers still seem to prefer to purchase in-season, close to the time of need.

So if enabling consumers to pre-order clothes is not the ideal solution, why not engage consumers just before the collections arrive in store? Based on the evidence of blowout events from Victoria?s Secret and H&M for Versace in New York earlier this month, consumer appetite for this kind of engagement, and the impact it has on sales, seem very promising indeed.

VICTORIA?S SECRET?S?GLOBAL?FASHION?EXTRAVAGANZA

The annual Victoria?s Secret fashion show is quite possibly the largest fashion event of its kind. From its humble beginnings in August 1995, with a budget of only $120,000, the Victoria?s Secret show has grown into a blockbuster multi-media event, with six different themes, featuring 38 models in 69 different looks, and costing more than $13m this year.

?Our show is seen, in one way or another, in over 200 countries in print, Facebook, YouTube, and television specials,? explained Ed Razek, Chief Marketing Officer of creative services of Limited Brands (the parent company of Victoria?s Secret) as we sat backstage before the first of two tapings of this year?s show. ?It is must-watch television for young women in the United States. They learn to walk in high heels in this show.?

While Mr. Razek explained how Victoria?s Secret has honed the show format over the past 16 years, Kanye West and the assembled Victoria?s Secret models were doing a backstage photo call in a crush of assembled media from China to Brazil. It could only be described as an all out media frenzy.

?Candidly, I think [the first show] was an aesthetic failure,? he said. ?We didn?t much know what we were doing, except the next day papers all over the world were calling it the lingerie event of the century. We knew that we had an idea.?

Over the years, the production values of the show and the quality of the collection have improved dramatically. Just last year, the brand began working with respected stylist and fashion editor, Sophia Neophitou-Apostolou, who is better known for her work with high-end fashion designers like Roland Mouret and Antonio Berardi. This year, Ms. Neophitou-Apostolou spent more than 40 days working on Victoria?s Secret runway collection, providing her input throughout the creative process.

Another parameter that has changed over the years is timing. The first show back in 1995 was held in August. For several years after that, the shows were held in the days preceding Valentine?s Day. But since 2001, the show has taken place in November, just in time for the holiday season. ?Christmas is the single biggest commercial opportunity of the year and it?s also a great time to do a fashion show special,? said Mr. Razek. This year?s show was taped on November 9th and will air on November 29th on?CBS, one of the three major American broadcast television networks.

Interestingly, the Victoria?s Secret show is not broadcast live, which Mr. Razek says comes down to maintaining production values and managing risk. ?You?re on network television in the United States. It is our responsibility to show our girls in their best light,? he said. ?The reward isn?t worth the risk. We want a beautifully produced show; something that is compelling and interesting.? In 2004, the Victoria?s Secret show was cancelled in the wake of the backlash following Janet Jackson?s so-called ?wardrobe malfunction? during the Superbowl half-time show.

But even without a live broadcast, Mr. Razek said: ?You see sales results almost immediately. On the night of the show you see substantial increases in our web business from all of the news coverage. The day after the fashion show runs [on television], you see substantial increases in our web business.?

While he declined to provide any detailed numbers to back this up, Victoria?s Secret Direct, which includes both the online and catalogue businesses, chalked up $1.5 billion in sales in 2010, roughly one-third of Victoria?s Secret?s overall sales. To provide a sense of scale, this makes Victoria?s Secret Direct about twice the size of Neiman Marcus Direct ($715 million in revenues in 2010) and more than eight times the size of Yoox or Net-a-Porter (about $200 million in annual sales each).

But importantly, the Victoria?s Secret show is about more than just driving online sales. It is the cornerstone of an integrated communications strategy that drives brand awareness as well as bolstering revenue across direct retail, catalogue and online channels.

Indeed, an integrated communications and sales strategy has long been part of the Victoria?s Secret?DNA. According to a case study published in 2002 by Tuck Business School at Dartmouth College, when Leslie Wexner bought Victoria?s Secret in 1982, he sought to make it ?stand [out] as an integrated world-class brand. Across all channels ? catalogue, stores, Internet ? the same products are launched at the same time, in exactly the same way, with the same quality, and same positioning.?

When asked to compare Victoria?s Secret?s marketing and communications initiatives to those deployed by luxury fashion brands, Mr. Razek offered: ?The obvious difference is that we?re showing fashion in real-time, during the season, things that are accessible in the stores now. They are showing Fall in Spring, Spring in Fall. How does the end customer connect with that, particularly with all of the live-streaming??

?They?re living in the past,? he concluded. ?There aren?t three fashion magazines anymore?the world is so broad, there are so many opportunities to communicate. You have to take advantage of them all. My personal opinion is that a substantial portion of the designer community is involved in an exercise of mass collective denial.?

H&M?FOR?VERSACE?INCITES?PANDEMONIUM

The day before the Victoria?s Secret show, H&M put on its own fashion spectacle in New York to celebrate its latest high-fashion collaboration, this time with Versace. With 500 fashion editors, bloggers and media from all over the world in town to cover the show, and a celebrity red carpet entrance to rival that of a major Hollywood event, this was another striking example of timing integrated brand communications to coincide with the arrival of product in stores.

The event began with a fashion show in an elaborate replica of the Versace show space in Milan at Pier 57, overlooking the Hudson River. When the show concluded, a beaming Donatella Versace unveiled a vast room behind the show space, filled with disco balls and an intimate stage set, where rising hiphop star Nicki Minaj soon took to the stage, decked out in Versace for H&M. Ms. Minaj?s performance was followed by an unforgettable thirty minute set from pop legend Prince.

All the while, anecdotes, photos and videos were being beamed out to the world via the Twitter, Instagram and Facebook accounts of the attendees. When the concert eventually concluded at 15 minutes past midnight, the walls opened up once more to reveal a fully-stocked Versace for H&M pop-up store, which created pandemonium unlike anything I have ever seen, and this, even amongst the fashion elite who have access to almost any kind of fashion they want.

As we waited in the crush to enter the store, someone asked American Vogue?s Hamish Bowles why he was subjecting himself to this kind of mob. ?It?s all a part of the experience,? he said, gesturing towards the shoppers stripping the mannequins bare, just behind a thick layer of burly security guards who were doing their best to hold back the throng. ?Please stand back,? they repeated. ?There is plenty of stuff for everyone.?

As it turned out, the security guards were wrong; most of the garments were gone within minutes as the first wave of shoppers snapped up everything in sight, filling four or five or six bags each with clothes. It was not a luxury shopping experience, that?s for sure, and the huge demand was in no small part due to prices which started at $17.95 for a pair of men?s printed underwear. But the collaboration couldn?t have come at a better time for Versace. It put a short, sharp spotlight on the once-struggling brand which is also having a bit of a fashion renaissance. East London creatives have been scouring vintage stores over the past couple of years to find vibrant Versace prints from the brand?s heyday in the late 1980s and early 1990s, when Versace was still at the head of the fashion vanguard.

?It is about bringing Versace to a whole new generation, and showing them the true essence of the house,? Donatella Versace told BoF.??Versace is already interacting with them in other ways. We are very active on Twitter and other social media. I think the Versace name is very powerful and the collaboration with H&M has allowed us to connect with even more people.? The day after the New York event, the show video was already available online, and a quirky fashion film was also rolled out across the fashion blogosphere.

Commenting on the immediate communications formula employed by H&M to promote the collaboration, Ms. Versace said: ?It made me think about how there are too many rules in fashion and how too often we get caught in these rules. I have never felt the need to follow the rules, but the system is so rigid these days with deadlines, so many collections to produce every year. This collaboration with H&M taught me that it was absolutely possible and necessary to break the rules.? she said. ?I really enjoyed working with a company that felt very strongly that we had to push things further.?

Last week, the collection finally arrived in cities around the world just as the Versace for H&M show buzz was cresting online, selling out almost immediately and crashing the H&M website under the weight of consumer demand.

LESSONS?FOR?FASHION?BRANDS

So, apart from synchronising the timing of brand communications and product delivery, what can a luxury fashion brand learn from these mass consumer fashion events?

Ms. Neophitou-Apostolou said that fashion brands need to learn to dream again. ?It?s about selling the dream, that?s the main thing. Don?t be too literal. Create the fantasy. Don?t be afraid of it,? she suggested a few days later, at a lunch in honour of Antonio Berardi. ?I think people become so concerned about: ?Is it wearable; Is it wearable?? McQueen in the day was always about fantasy. John Galliano was always about fantasy. Even Azzedine [Ala?a] takes you on a journey; in his little shows he creates his own universe. I think that?s the trick. Don?t be afraid to dream!?

That said, ?every [look in the Victoria?s Secret show] has a piece of product so you can physically buy the pieces,? Ms. Neophitou-Apostolou continued, but these were mixed in with dream-like pieces including the now famous angel wings. ?It?s the best piece of marketing I?ve ever been involved with,? she added.

Indeed, the consumer events in New York couldn?t have been more different from fashion shows designed for an industry audience. They must be conceived and designed to have maximum impact on screen, drive online conversation, and ultimately drive sales online and in-store.

Even for a behemoth like H&M, this kind of initiative requires a huge investment of time and resources. ?It?s a huge undertaking to organise a fashion show for editors from all 41 markets,? said Margareta van den Bosch, Creative Director of H&M.

What?s more, having an integrated supply chain from design to production to retail, makes it much easier to align the communications and sales cycles. According to the Tuck Business School case, Victoria?s Secret is ?equipped with vertically integrated factories that manufacture and deliver goods directly to the company without the involvement of third party intermediaries.?

?We own all our own stores,? added Mr Razek. ?There aren?t any buyers from department stores sitting in the front row writing orders. Our ultimate customer is not a merchant with a pencil, which is different from most designers.?

Imran Amed is founder and editor of The Business of Fashion

Source: http://www.businessoffashion.com/2011/11/addressing-fashions-communications-conundrum.html

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Romney to run first TV ad of presidential race (AP)

MANCHESTER, N.H. ? Mitt Romney is going on the air with a television ad timed to coincide with President Barack Obama's visit to New Hampshire on Tuesday.

The former Massachusetts governor says his first ad of the presidential race will feature Obama talking about the economy in the state that will hold the first presidential primary in the nation on Jan. 10

Romney tells Fox News that Obama promised to get the economy moving, bring people together and be a real leader for change in America.

But Romney says the contrast between what Obama said and did in office is so "stark" that people will recognize that the country needs new leadership.

He says the ad will say why he alone is the right person to lead the country.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20111121/ap_on_el_ge/us_romney

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Tuesday, November 22, 2011

Giving thanks helps your psychological outlook (AP)

WASHINGTON ? Count your blessings this Thanksgiving. It's good for you.

While it seems pretty obvious that gratitude is a positive emotion, psychologists for decades rarely delved into the science of giving thanks. But in the last several years they have, learning in many experiments that it is one of humanity's most powerful emotions. It makes you happier and can change your attitude about life, like an emotional reset button.

Especially in hard times, like these.

Beyond proving that being grateful helps you, psychologists also are trying to figure out the brain chemistry behind gratitude and the best ways of showing it.

"Oprah was right," said University of Miami psychology professor Michael McCullough, who has studied people who are asked to be regularly thankful. "When you are stopping and counting your blessings, you are sort of hijacking your emotional system."

And he means hijacking it from out of a funk into a good place. A very good place. Research by McCullough and others finds that giving thanks is a potent emotion that feeds on itself, almost the equivalent of being victorious. It could be called a vicious circle, but it's anything but vicious.

He said psychologists used to underestimate the strength of simple gratitude: "It does make people happier ... It's that incredible feeling."

One of the reasons why gratitude works so well is that it connects us with others, McCullough said. That's why when you give thanks it should be more heartfelt and personal instead of a terse thank you note for a gift or a hastily run-through grace before dinner, psychologists say.

Chicago area psychologist and self-help book author Maryann Troiani said she starts getting clients on gratitude gradually, sometimes just by limiting their complaints to two whines a session. Then she eventually gets them to log good things that happened to them in gratitude journals: "Gratitude really changes your attitude and your outlook on life."

Gratitude journals or diaries, in which people list weekly or nightly what they are thankful for, are becoming regular therapy tools.

And in those journals, it is important to focus more on the people you are grateful for, said Robert Emmons, a psychology professor at the University of California, Davis. Concentrate on what life would be without the good things ? especially people such as spouses ? in your life and how you are grateful they are there, he said.

Grateful people "feel more alert, alive, interested, enthusiastic. They also feel more connected to others," said Emmons, who has written two books on the science of gratitude and often studies the effects of those gratitude diaries.

"Gratitude also serves as a stress buffer," Emmons said in an e-mail interview. "Grateful people are less likely to experience envy, anger, resentment, regret and other unpleasant states that produce stress."

Scientists are not just looking at the emotions behind gratitude but the nuts-and-bolts physiology as well.

Preliminary theories look at the brain chemistry and hormones in the blood and neurotransmitters in the brain that are connected to feelings of gratitude, Emmons said. And the left prefrontal cortex of the brain, which is also associated with positive emotions like love and compassion, seems to be a key spot, especially in Buddhist monks, Emmons said.

However it works in the brain, Emmons said there is little doubt that it works.

Emmons, who has conducted several studies on people from ages 12 to 80, including those with neuromuscular disease, asked volunteers to keep daily or weekly gratitude diaries. Another group listed hassles, and others just recorded random events. He noticed a significant and consistent difference. About three-quarters of the people studied who regularly counted their blessings scored higher in happiness tests and some even showed improvements in amounts of sleep and exercise.

Christopher Peterson of the University of Michigan studied different gratitude methods and found the biggest immediate improvement in happiness scores was among people who were given one week to write and deliver in person a letter of gratitude to someone who had been especially kind to them, but was never thanked. That emotional health boost was large, but it didn't last over the weeks and months to come.

Peterson also asked people to write down nightly three things that went well that day and why that went well. That took longer to show any difference in happiness scores over control groups, but after one month the results were significantly better and they stayed better through six months.

Peterson said it worked so well that he is adopted it in his daily life, writing from-the-heart thank you notes, logging his feelings of gratitude: "It was very beneficial for me. I was much more cheerful."

At the University of North Carolina, Sara Algoe studied the interaction between cancer patients and their support group, especially when acts of gratitude were made. Like Peterson, she saw the effects last well over a month and she saw the feedback cycle that McCullough described.

"It must be really powerful," Algoe said.

It has to be potent to combat gloom many may be feeling in such uncertain times.

There have been many Thanksgivings throughout history that might challenge society's ability to be grateful. The first Thanksgiving with the Pilgrims came after about half of the Plymouth colony died in the first year. Thanksgiving became a national holiday in the United States when Abraham Lincoln proclaimed it in 1863 during the Civil War, the deadliest war the country has ever known. And the holiday moved to the fourth Thursday in November during the tail end of the Great Depression.

Emmons actually encourages people to "think of your worst moments, your sorrows, your losses, your sadness and then remember that here you are, able to remember them. You got through the worst day of your life ... remember the bad things, then look to see where you are."

That grace amid difficulty motif may make this Thanksgiving especially meaningful, McCullough said.

"In order to be grateful for something, we have to remember that something good happened," Peterson said. "It's important to remind ourselves that the world doesn't always suck."

___

Online:

Robert Emmons: http://psychology.ucdavis.edu/labs/emmons/PWT/index.cfm

National Association of School Psychologists' tips on fostering gratitude in children: http://bit.ly/rHlqCz

Source: http://us.rd.yahoo.com/dailynews/rss/science/*http%3A//news.yahoo.com/s/ap/20111123/ap_on_sc/us_sci_psychology_of_thanks

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