Cellular fuel gauge may hold the key to restricting cancer growth

Dec. 27, 2012 ? Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts as a "fuel gauge" in cells; AMPK is turned on when it senses changes in energy levels, and helps to change metabolism when energy levels are low, such as during exercise or when fasting. The researchers found that AMPK also regulates cancer cell metabolism and can restrict cancer cell growth.

The discovery was made by Russell (Rusty) Jones, an assistant professor at McGill's Goodman Cancer Research Centre and the Department of Physiology, Faculty of Medicine. Jones along with his team is the first to show that AMPK can act as a tumour suppressor in animals. The research will be published December 27 in the journal Cell Metabolism.

"Cancer is a disease in which cells lose their normal restraints on growth and start to divide uncontrollably. But, in order for cells to grow quickly they need enough energy to complete the task," Jones explained. "AMPK acts like the fuel gauge in your car -- it lets the body know when energy levels are low, and stops cell growth until there is enough gas in the tank. We wanted to see if this fuel gauge could affect the development and progression of cancer. We found that mice lacking AMPK developed tumours faster, suggesting that AMPK is important for keeping tumour development in check, at least for some types of cancer." For this study, Jones' team focused specifically on a type of blood cancer known as lymphoma. They discovered that the protein Myc, which is activated in more than half of all cancers, could promote lymphoma more rapidly when mice were deficient for AMPK.

One of the ways cancer cells support their enhanced rate of growth is by changing their metabolism, or how they generate energy. Cancer cells are different from normal cells in our body because they preferentially use sugar to fuel their growth. Jones discovered that AMPK plays a specific role in restricting cancer cells' ability to use sugar to fuel their growth. "For cancer cells with low AMPK levels, their metabolism goes into overdrive," explained Prof. Jones. "They use sugar more efficiently, allowing them to grow faster. These results suggest that turning on AMPK in cancer cells may be one way that we can restrict cancer growth."

Jones' breakthrough builds on his previous discovery that the widely prescribed medication metformin, a common diabetes drug, can restrict tumour cell growth. The results bring promise that common therapeutics that turn on AMPK and alter cellular metabolism, such as metformin, may become novel tools for cancer therapy. Jones and his colleagues at McGill are currently exploring clinical applications based on this research.

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The above story is reprinted from materials provided by McGill University, via EurekAlert!, a service of AAAS.

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Journal Reference:

1. Brandon Faubert, Gino Boily, Said Izreig, Takla Griss, Bozena Samborska, Zhifeng Dong, Fanny Dupuy, Christopher Chambers, Benjamin?J. Fuerth, Benoit Viollet, Orval?A. Mamer, Daina Avizonis, Ralph?J. DeBerardinis, Peter?M. Siegel, Russell?G. Jones. AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In?Vivo. Cell Metabolism, 2012; DOI: 10.1016/j.cmet.2012.12.001

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/S3OtxBo-Q-Q/121227130327.htm

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Can Obama Avert the Fiscal Cliff without Mitch McConnell? (Atlantic Politics Channel)

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Chinese leaders promise reform, spending if needed

BEIJING (AP) ? China's new Communist Party leaders are promising reforms aimed at reducing reliance on exports and more spending if needed to prop up a shaky economic recovery.

In the first statement of their economic goals since taking power in November, the new party leaders pledged continuity Sunday with long-term plans aimed at nurturing self-sustaining growth and raising incomes. There was no indication of plans for major changes or new stimulus.

They promised to support domestic consumption, the growth of small businesses that generate jobs and more migration by rural residents into expanding cities to find better-paid jobs.

The new party general secretary, Xi Jinping, and other leaders are under pressure to overhaul an economic model based on exports and investment that delivered three decades of rapid growth but is running out of steam. Companies and political analysts are watching to see how far they are willing to go in remodeling the state-dominated economy.

In the shorter term, they also need to keep a recovery from China's deepest economic downturn since the 2008 global crisis on track.

Party leaders promised a "proactive fiscal policy" and "prudent monetary policy" in a statement distributed by the official Xinhua News Agency at the end of a two-day annual planning meeting. That refers to willingness to boost government spending if needed and to keep credit easy so long as inflation stays low.

The world's second-largest economy is limping out of the slump that pushed growth to a three-and-a-half-year low of 7.4 percent in the latest quarter but weak November trade data suggested the rebound might be faltering.

The World Bank and other analysts say Beijing needs to curb dominant state companies and promote service industries and consumer spending to keep incomes rising. They say without prompt action, growth might slow abruptly, leaving China stuck at middle-income levels.

Possible reforms face potential opposition from state companies that might see their privileges diminished and have influential allies in the party.

"If China does not change its strategy, it risks falling into the 'middle income trap'," Robert Zoellick, former World Bank president, said in a speech at a Beijing business conference last week.

In a tacit acknowledgement of possible obstacles, Sunday's statement said change would require "greater political courage and wisdom."

The new leadership promised to "accelerate structural reform," open markets further and encourage efficiency, though they gave no details of possible changes. It said "enhancing quality and efficiency of economic growth" will be a "central task."

Factory output, consumer spending and other indicators are improving in the current quarter but analysts say a recovery is likely to be gradual and too weak to drive a global rebound without improvement in Europe and the United States.

Data last week showed November trade deteriorated sharply following a rebound that started in August. Export growth plunged to 2.9 percent over a year earlier from October's 11.6 percent. Imports were flat, down from October's 2.4 percent growth.

Sunday's statement gave no indication the leadership plans to depart from the party's official annual economic growth target of 7.5 percent through 2015.

It promised to support the orderly growth of cities, a key element in raising incomes by allowing migrants from the countryside to look for better-paid urban jobs.

The leadership pledged to increase domestic demand, though it gave no details of how it will do that.

Companies are under pressure to help boost consumer spending by putting more money in workers' pockets through wage hikes. Other changes require longer-term effort, such as freeing up money in household budgets by raising government spending on schools, health care and other social programs.

Sunday's statement promised one step in that direction: more spending on building affordable housing and other initiatives aimed at spreading money to China's poor.

Earlier statements by the new leadership suggested they want to narrow China's yawning and politically sensitive wealth gap between an elite who have benefited from economic reform and the poor majority.

The new party Politburo pledged this month to pursue both economic growth and "social harmony and stability."

The government is due to release a long-awaited report this month on proposals for policy changes to narrow the wealth gap.

Source: http://news.yahoo.com/chinese-leaders-promise-reform-spending-needed-025859281--finance.html

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On foreign policy, Kerry is Obama's good soldier

WASHINGTON (AP) ? Democratic Sen. John Kerry stands tall as President Barack Obama's good soldier.

The Massachusetts lawmaker has flown to Afghanistan and Pakistan numerous times to tamp down diplomatic disputes, spending hours drinking tea and taking walks with Afghan President Hamid Karzai or engaging in delicate negotiations in Islamabad.

It's a highly unusual role for a Senate Foreign Relations Committee chairman: envoy with a special but undefined portfolio.

Kerry has pushed the White House's national security agenda in the Senate with mixed results. He successfully ensured ratification of a nuclear arms reduction treaty in 2010 and most recently failed to persuade Republicans to back a U.N. pact on the rights of the disabled.

Throughout this past election year, he skewered Obama's Republican rival, Mitt Romney, at nearly every opportunity and was a vocal booster for the president's re-election. Kerry memorably told delegates at the Democratic National Convention in August: "Ask Osama bin Laden if he's better off now than he was four years ago."

Obama seems likely to reward all that work by nominating the 69-year-old Kerry, perhaps in the coming days, to succeed Secretary of State Hillary Rodham Clinton as the nation's top diplomat. The prospects for the five-term senator soared last week when U.N. Ambassador Susan Rice, a top contender for the post, withdrew from consideration to avoid a fierce fight with Senate Republicans.

A Kerry nomination has been discussed with congressional leaders, and consultations between the White House and congressional Democrats have centered on the fate of his Senate seat, according to officials familiar with the situation who were not authorized to publicly discuss the talks. If the seat were in play, it could boost the prospects for recently defeated Republican Sen. Scott Brown to win back a job in Washington.

At the same time, Obama is considering one of Kerry's former Senate colleagues, Republican Chuck Hagel of Nebraska, for the Pentagon's top job.

The selection of Kerry would close a political circle with Obama. In 2004, it was White House hopeful Kerry who asked a largely unknown Illinois state senator to deliver the keynote address at the Democratic convention in Boston, handing the national stage to Obama. Kerry lost that election to President George W. Bush. Four years later, Obama was the White House hopeful who succeeded where Kerry had failed.

Senate colleagues in both parties say Kerry's confirmation would be swift and near certain, another remarkable turnaround. Eight years ago, the GOP ridiculed Kerry as a wind-surfing flip-flopper as he tried and failed to unseat Bush.

"If he is nominated, he comes into the position with a world of knowledge. He's someone who certainly understands how the legislative process works, and I think he will be someone that Congress will want to work with in a very positive way," said Sen. Bob Corker of Tennessee, who is poised to become the top Republican on the Foreign Relations Committee next year.

Sen. Kelly Ayotte, R-N.H., a member of the Senate Armed Services Committee, said "there's no question he has a very strong depth of knowledge of these issues. Certainly qualified."

Sen. John McCain, R-Ariz., has taken to jokingly referring to Kerry as "Mr. Secretary."

Kerry and McCain, defeated presidential candidates who returned to the Senate, have joined forces repeatedly during the past few decades. In July 1995, the two decorated Vietnam War veterans provided political cover to President Bill Clinton when he normalized U.S. relations with Vietnam. Clinton had been dogged by questions about his lack of military service.

Last year, Kerry and McCain were outspoken in pushing for a no-fly zone over Libya as Moammar Gadhafi's forces attacked rebels and citizens. This month, they stood together in arguing for the disabilities treaty against staunch Republican opposition and complaints that it could undermine U.S. national sovereignty.

The pact fell five votes short of ratification, and Kerry called it "one of the saddest days I've seen" in his years in the Senate.

"Today I understand better than ever before why Americans have such disdain for Congress and just how much must happen to fix the Senate so we can act on the real interests of our country," he said, his frustration evident.

Kerry has traveled extensively for the administration, to Afghanistan in May as a strategic partnership agreement loomed large in the decade-plus war. He was in Pakistan last year in the midst of a diplomatic crisis after Raymond Davis, a CIA-contracted American spy, was accused of killing two Pakistanis.

Sen. Chris Coons, D-Del., a member of the Foreign Relations Committee, traveled to Pakistan around that time and recalled Kerry's influence.

"I arrived in Islamabad I think five days after Ray Davis had been taken into a jail in the Punjab and was at very real risk of being hauled out of the jail and lynched," Coons said. "Sen. Kerry was about to show up and negotiate on behalf of the administration. And it was clear that both the diplomats and the military folks we met with viewed him as a real man of credibility and experience who was likely to contribute meaningfully to those negotiations."

Davis pleaded self-defense. After weeks of wrangling between the U.S. and Pakistan, he was released in exchange for "blood money" paid to the dead men's relatives.

This year, Kerry has presided over committee hearings on treaties and other major issues, but there has been little legislative work. He didn't draw much attention to the committee, avoiding possible embarrassments for the administration in an election year.

Corker said he would have liked for the committee to devote more time to events in Libya, Syria and other countries.

"I think he's tried to accommodate our concerns and at the same time seek a balance ... giving the administration the headroom they needed to do what he and the administration felt was best. I understand that," he said, speaking of Kerry.

Coons said Kerry's deliberate work is often behind the scenes.

"The role of the chairman ... is not always getting your picture taken with George Clooney, standing around with heads of state, going to receptions in Foggy Bottom," he said. "It's also lots and lots of time listening to folks who've got concerns whether it's on behalf of the defense community, the business community, the diplomatic community and being the person who's at the intersection of all that and trying to keep the Senate productively engaged in a very dangerous world with a lot of emerging threats."

___

Associated Press writer Steve Peoples in Boston contributed to this report.

___

Donna Cassata can be reached on Twitter at http://twitter.com/DonnaCassataAP

Source: http://news.yahoo.com/foreign-policy-kerry-obamas-good-soldier-173621370--politics.html

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PFT: Polamalu to have 'significant role' this week

Reuters

Amid rampant reports and rumblings that Eagles quarterback Mike Vick believes the team is using his concussions as an excuse to keep him on ice while the team tries out younger players, the Eagles have issued a statement from Vick.

But the statement omits any clear statement from Vick that he believes the Eagles aren?t putting a thumb on the concussion assessment scale.

?I want to thank my fans for the thousands of well wishes,? Vick says.? ?I also appreciate the support of the entire Eagles organization. I feel strong and healthy. ? As a professional athlete, I want to play in every game but the NFL has a specific protocol to protect players.?? My focus is to complete this process successfully, so I can rejoin my team on the field.?

Earlier in the day, coach Andy Reid addressed more specifically the question of whether politics are keeping Vick on ice.

?[T]here?s nothing to that,? Reid told reporters.? ?I?ve talked with Michael and Michael is good.? I don?t know where things get started but Michael is fine with it.? He understands that everything is in the best interest of him right now and making sure that he?s ready to go.?

Reid also essentially said that, when Vick is cleared to play, he will.? ?Michael is the quarterback of this team,? Reid said.? ?That?s how I?ve approached it from the get go.? I?ve told you guys that.? Until I tell you guys differently, that?s how I feel.? Michael understands that so that?s the important thing.? I just want to make sure there?s open communication between us.?

Trainer Rick Burkholder said that reports Vick have regressed aren?t true, but that Vick has plateaued in his recovery.? Burkholder also disputed the suggestion that the concussion is being used as a way to justify not playing Vick; ?There?s no conspiracy here,? Burkholder said.

Still, the suspicion has been present from the outset that Vick isn?t injured as badly as advertised, and that the concussion allowed the Eagles to bench him without actually benching him.? From Vick?s perspective, not playing makes it hard to persuade other teams that he deserves a starting job and the contract that goes along with it after the Eagles inevitably cut him in the offseason, avoiding a $15.5 million salary for 2013.

And even if the Eagles aren?t fudging the concussion assessment results (indeed, there?s no evidence that they are), there?s a good chance they?re privately pleased with the situation, since it allows them to give Nick Foles extended reps and development.? As Reid said Friday regarding the decision to cut defensive end Jason Babin, ?It gives some of our young players, who I think deserve the right and can help us win football games, the opportunity to play.?

That same reasoning applies to Foles.? Even though he has yet to help them do anything other than lose football games.

Source: http://profootballtalk.nbcsports.com/2012/11/30/steelers-expect-polamalu-to-have-significant-role-this-week/related

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Seniors and Baby boomers Online Dating Guide - How to date the ...

Seniors and Baby boomers Online Dating Guide

Online dating is a kind of tide.
Now Online dating is not just for young people any more. Thousands of older singles are reaching out for new ways to meet up and start a new life together. Matchmaking websites report significant increases in senior dating, specifically among those ages 50 to 65.
If you?re older than 45 and looking for love online, senior dating on the Internet can be a great way to find Romantic love. Over 45 is a very romantic time in your life. People generally become more romantic as they get older as they learn to savour the finer things in life.?But, Just as you take steps to ensure your in-person dating experience is the best it can be, you should also follow a few guidelines for online dating.

Tip 1: Know what you want
Online dating is different from traditional dating in many ways. In the old days, you might meet someone interesting at a social event, church group, a bar or even at work. Perhaps the person?s looks or laugh would attract you, and you?d make that initial connection in person.
When dating online, you need to be very clear on what you?re looking for. Because online dating site databases have thousands of members. You?ll have to search through databases of other people, just like you, are looking for love. Narrow your search by deciding in advance what kind of relationship you want (friendship, romance, long-term), the age range you?re comfortable with, whether you?re OK meeting someone who has kids, what interests you would like the person to share, and whether religion or politics will matter to you.
Make a list of all these important factors before you begin your search, so that you can narrow down your results and have a better chance of meeting someone compatible.
Tip 2: Look in the right places
Google the words ?online dating? and you?ll get about 175 million results. That?s a lot of people looking to make a connection. Narrow your search for love by sticking with sites that cater to your age group and interests. I recommend a dating site----- http://www.50romance.com/ , a website for baby boomers and seniors, attracts online daters in the 50-plus age range. Each of these members are true. Background services have a professional team, to assist you in finding that someone special, from casual daters to serious singles.
By searching on sites frequented by people in your age range, and that share your interests, you?re more likely to find compatible people for friendship and dating.
Tip 3: Be honest, but not too open
Age is just a number. It?s never too late to fall in love. Honesty is the foundation of any good relationship, and it?s important to be yourself when dating online. Be honest about your age, lifestyle, interests and what type of relationship you seek.
When making new connections, proceed with caution. Don?t put too much personal, identifying information in your user profile. While the majority of online daters have good intentions, identity thieves have been known to approach potential victims online.
Tip 4: Take care
When you meet your love online, start out slowly and get to know each other through email and instant messages before you arrange a phone call. Never agree to meet someone you?ve met online until you?ve gotten to know each other a little bit first. And when you do arrange that exciting first date, make sure a friend or family member knows where you will be, who you?ll be with and when you expect to be back from your date.
In this age of information, online dating have been integrated into the people in the life. More seniors and baby boomers than ever are discovering love online. With the right preparations and precautions, you can help ensure you make some great connections on the information superhighway.

Source: http://50romance.blogspot.com/2012/11/seniors-and-baby-boomers-online-dating.html

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Daughter of Gaddafi's ex-spy chief says jailed father very sick

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Your response will be seen by your Facebook friends on Yahoo!\",\"NUM_PEOPLE_RATED__s1\":200008,\"NUM_PEOPLE_RATED__s2\":12555,\"NUM_PEOPLE_RATED__s3\":9664,\"NUM_PEOPLE_RATED__s4\":9199,\"NUM_PEOPLE_RATED__s5\":10632,\"NUM_PEOPLE_RATED__s6\":199967,\"NUM_PEOPLE_RATED__s7\":0,\"NUM_PEOPLE_RATED__s8\":0,\"NUM_PEOPLE_RATED__s9\":0,\"NUM_PEOPLE_RATED__s10\":0}","fbconfig":"{\"message\":\"undefined\",\"name\":\"undefined\",\"link\":\"\",\"source\":\"\",\"picture\":\"http:\\\/\\\/l.yimg.com\\\/a\\\/i\\\/ww\\\/news\\\/2011\\\/09\\\/27\\\/yahoo-tc.jpg\",\"description\":\"\",\"captionLeft\":\"undefined\",\"captionRight\":\"undefined\",\"app_id\":\"196660913708276\",\"redirect_uri\":\"\\\/_xhr\\\/ugcratefbredirect\\\/\"}","template_id":"LONG_SLIDER_SOUTH","obj_id":"ratings_240cf625f097ce0da50503e11394e761","opt_count":"6","opt_color1":"","opt_color2":"","template_html":"

Source: http://news.yahoo.com/daughter-gaddafis-ex-spy-chief-says-jailed-father-135428870.html

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Iran hikes domestic airfares by up to 70 percent

TEHRAN, Iran (AP) ? Iranian local airlines have increased their airfares by up to 70 percent amid Western sanctions on the oil and banking system, the official IRNA news agency reported on Tuesday.

The report quotes Hamid Reza Pahlevani, head of the country's aviation organization, as saying it authorized airlines to increase the airfares to compensate for the high price of aircraft fuel by Iran's state-owned fuel company.

The hike is the biggest increase in local airfares since the early 1990s. Iranian airliners in recent years had occasionally raised the fares by lower amounts, such as 20 to 30 percent.

In May, Iran doubled price of fuel for Iranian airlines, which are mostly state-owned.

The move is seen as part of the country's plan to cut fuel and food subsidies, which began in late 2010 amid sanctions on oil and the banking system by the West over Tehran's disputed nuclear program.

In the past, the airlines received their imported needs based on the U.S. dollar trading at around 12,260 Iranian rials. In recent weeks, government has been organizing their imported needs based on a new calculation, almost double the previous one.

Since the banking and oil embargo in July by the European Union, the rial has fallen drastically in value against foreign currencies.

The slide has accelerated over the past month. Iranian politicians blame the drop on the sanctions but also on alleged mismanagement by the government of President Mahmoud Ahmadinejad.

On Tuesday, the rial traded at 31,000 to the dollar. The rate was about 11,000 in mid-2011. In early October, it jumped to more than 36,000 rials from around 27,000 just a week.

Meanwhile, the semi-official Mehr news agency said some 20 lawmakers have proposed a bill obliging Tehran to temporarily reduce its oil exports to the countries that observe sanctions against Iran by 33 percent.

Lawmaker Masoud Mir Kazemi and the head of parliament's energy committee supported the bill, saying "we are able to use oil as a response to the sanctions."

The bill is expected to be discussed next week.

Many countries, including China, Japan, South Korea, India and Turkey have decreased oil import from Iran after the EU-imposed oil embargo on the country.

The West suspects Iran is pursuing a nuclear weapons program. Iran denies the charge, saying its nuclear activities are aimed at peaceful purposes like power generation and cancer treatment.

Source: http://news.yahoo.com/iran-hikes-domestic-airfares-70-percent-192150048--finance.html

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For the Forensic Technology - Computers and Technology

Forensic technology means scientific evidence has been used in criminal proceedings in a wide range. These scientific findings of the physical collection and analysis occurs. Principles to be used as evidence or determine civil or criminal proceedings in this type of technology has focused a lot of new aspects.

One of the technical areas that promise a lot of digital software. Criminals and terrorists have the ability to carry out a variety of electronic devices to use their own crimes. A digital component of the increase in crimes of the security that is required to have equipment for crime. Digital is reformatted or partitioned case, a computer forensic data recovery software is capable of

Others are software programs that:

? A program to erase a hard drive clean
? Log in to find spyware hidden partitions, plus some large fast hard drives and more.
? to analyze disk images ?flat? in the image can be compressed
Check all parts of a hard drive, and turn around or even hide ? ?supervisor?
? blocking a new writing program protects your computer information more effectively in previous programs

Image analysis of forensic science that interprets the contents of the image. Many companies reduce costs and accelerate research occurred efficient appliances. Compare features photos, content analysis, photogrammetry (using photography to make the measurements) to make and is designed for image authentication. With a variety of techniques, mega data and video aspect ratios PIXIL error, pictures and animations are used to extract information. This is true even if one tries to present evidence for one hour.

One of the new tools of scientific research and evaluation of evidence is primarily a series of multimedia legal issues, there are video forensics. The objective of this technique, a judge and jury, the evidence to determine civil or criminal case, the decision to produce an accurate picture. In addition to this new technology to improve video images grainy photographs, refined, and the development of a person or an object in an application of video image processing, in addition to converting the digital video in some form for forensic analysis. The work in this type of law enforcement, security, surveillance and even for military operations is important in solving cases.

Data recovery is a process used for lawful purposes, in order to retrieve data from computers. Aware that most people are much more difficult to erase all information from a computer. Objective data recovery is to go your missing or deleted. Mined data collection, analysis, and then the process is using protection. Successful completion of these measures, data loss is to provide the court with a computer expert. This technology is available to provide the court as evidence in civil or criminal proceedings.

Explains the forensic evidence that can be used in court, then it should be required to science and technology to meet the supply that evidence. The chain of custody in the courtroom will be kept in mind that a criminal investigation, the creation of well-studied the facts and evidence to occur legally. The lower part of the study area within the existing firewall forensics, database and mobile device forensics is forensics.

Source: http://www.vblite.org/for-the-forensic-technology-what-is-it.html

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Twitter sees new record during Euro 2012 final

Spain's Fernando Torres holds his son Leo after an award ceremony as Spain won the Euro 2012 soccer championship final between Spain and Italy in Kiev, Ukraine, early Monday, July 2, 2012. (AP Photo/Vadim Ghirda)

Spain's Fernando Torres holds his son Leo after an award ceremony as Spain won the Euro 2012 soccer championship final between Spain and Italy in Kiev, Ukraine, early Monday, July 2, 2012. (AP Photo/Vadim Ghirda)

WARSAW, Poland (AP) ? Twitter says its users fired off more than 15,000 tweets per second when Spain scored its fourth goal in Sunday's European Championship final, setting a sports-related record on the social networking site.

The surge in tweets came just weeks before the Olympic Games in London are expected to spur more record-setting activity on social networking sites ? from tweets to postings of photos and other user-generated material.

Twitter said it registered a total of 16.5 million tweets worldwide during the soccer match Sunday in Kiev, where Spain defeated Italy 4-0. It said total global traffic on its platform peaked at 15,358 tweets per second as Spain scored its fourth goal, a record for a sporting event.

"Commentators, fans and athletes around the world supported their teams in song, in face paint and in tweets" throughout the Euro 2012, Twitter said in a blog.

As fans increasingly use social media to connect during major sports competitions, new "tweet per second" records are constantly being set.

Twitter registered a peak of 12,233 tweets per second during the final three minutes of the Super Bowl in February.

An earlier record was set during the final match of the 2011 Women's World Cup, a match in Germany that saw 7,196 tweets per second, including 13 from President Barack Obama. In that game, Japan's team defeated the U.S. on penalty kicks following a 2-2 draw.

Among those who tweeted Sunday was Pele, the retired Brazilian star. He congratulated Spain and said he was looking forward to the 2014 World Cup in Brazil.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2012-07-02-Euro%202012-Twitter%20Record/id-45faae9048cb49898924037a048d51ab

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Spain wins again, beating Italy 4-0 at Euro 2012

Spain's David Silva scores a goal during the Euro 2012 soccer championship final between Spain and Italy in Kiev, Ukraine, Sunday, July 1, 2012. (AP Photo/Jon Super)

Spain's David Silva scores a goal during the Euro 2012 soccer championship final between Spain and Italy in Kiev, Ukraine, Sunday, July 1, 2012. (AP Photo/Jon Super)

Spain's Jordi Alba celebrates their second goal with teammates during the Euro 2012 soccer championship final against Italy in Kiev, Ukraine, Sunday, July 1, 2012. (AP Photo/Matthias Schrader)

Spain head coach Vicente del Bosque, left, kicks the ball as Italy's Federico Balzaretti tries to take a throw-in during the Euro 2012 soccer championship final between Spain and Italy in Kiev, Ukraine, Sunday, July 1, 2012. (AP Photo/Ivan Sekretarev)

Italy's goalkeeper Gianluigi Buffon reacts after Spain's David Silva, left, scored the opening goal during the Euro 2012 soccer championship final between Spain and Italy in Kiev, Ukraine, Sunday, July 1, 2012. (AP Photo/Ivan Sekretarev)

Italy goalkeeper Gianluigi Buffon make a save in front of Spain's Cesc Fabregas during the Euro 2012 soccer championship final between Spain and Italy in Kiev, Ukraine, Sunday, July 1, 2012. (AP Photo/Matthias Schrader)

KIEV, Ukraine (AP) ? The defense was impenetrable. The offense was unstoppable. Simply put, it was another Spanish party on the international stage.

Spain won its third straight major soccer title Sunday, routing Italy 4-0 in the European Championship final and making it look all too easy.

David Silva and Jordi Alba scored first-half goals, and substitutes Fernando Torres and Juan Mata added two more in the final minutes as the Spanish passing game worked its magic against the Italians at the Olympic Stadium.

Silva headed in a high shot in the 14th minute off a pass from Cesc Fabregas. And Alba added another in the 41st, picking up a beautiful through ball from Xavi Hernandez and shooting past Italy goalkeeper Gianluigi Buffon.

Torres, who came on for Fabregas in the 75th minute, added the third goal with an easy finish and Mata really put the game away in the 88th, knocking in a pass from Torres.

"They were a great rival, but we took control of the game as time went by," Spain coach Vicente del Bosque said.

Spain won the Euro 2008 title four years ago in Vienna and followed that up with the World Cup title in Johannesburg two years ago.

"They had made history before, and I could now," said Alba, who has played only nine matches for Spain. "I don't believe it but little by little it is sinking in."

Torres also scored the lone goal in the 1-0 win over Germany in 2008, making him the first man to score in two European Championship finals.

Not only has Spain won every knockout game since losing to France in the second round of the 2006 World Cup, but goalkeeper Iker Casillas hasn't allowed a goal in that 10-game span. The last player to beat him is such an important match was Zinedine Zidane, and he retired after that tournament.

Sunday's win was a record 100th for Casillas in international soccer.

Spain was the favorite heading into the match, but also seemed primed for a loss after being held to a 1-1 draw by the Italians in their opening Group C match. Spain, which has been experimenting with a lineup that excludes a recognized striker, needed a penalty shootout to reach the final after a 0-0 tie with Portugal in the semifinals.

The controversial lineup, which Del Bosque again employed on Sunday, is akin to playing in the Super Bowl without a running back. Sure, you can still score touchdowns, but you give up on the chance for a game-breaking play.

Spain did just fine without the strikers, but they did even better when Torres came on. Although he has struggled both for Spain and Chelsea recently ? and was relegated to the bench for four of the six games at Euro 2012 ? Torres came on Sunday and made a difference.

But as good as the play was up front for Spain, it was the steady hands of Casillas at the back that likely preserved the victory.

Casillas made a point-blank save on a shot from Antonio Di Natale at the start of the second half, and twice tipped crosses out of danger just before the Italians could get their heads to the ball.

With every save, and of course with every goal, the huge group of Spain supporters cheered and screamed. The red-shirted fans dominated one corner of the stadium, filling up more than six sections of the Olympic Stadium. On the opposite side, the blue-clad Italians were far outnumbered, with dozens of empty yellow seats poking through the mass of supporters.

The political aspect of the game involved several heads of state. Italian Premier Mario Monti, along with other EU leaders, had said they would not travel to Ukraine for the tournament because of the politically tainted jailing of former Prime Minister Yulia Tymoshenko. But that didn't stop him from attending the final in Kiev.

Spanish Prime Minister Mariano Rajoy also attended the match, and got to watch as his players celebrated with confetti and fireworks when they lifted yet another major trophy.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-07-01-SOC-Euro-2012-Final/id-2bf9913de94e41559cbff521598be5e6

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U.S. Task Force's Recommendations Stoke Debate over Calcium and Vitamin D Supplements

News | Health

A task force found insufficient evidence to recommend supplements to healthy people to prevent broken bones or cancer, but this could overlook several categories of people

By Melinda Wenner Moyer ?| July 2, 2012?|

Image: Wikimedia Commons/Ragesoss

If you are healthy, living at home, and take calcium and vitamin D supplements to prevent broken bones or cancer, you may want to reconsider, according to the U.S. Preventive Services Task Force (USPSTF). The group's new draft recommendations, published online on June 12, add more fervor to the ongoing debate about the benefits and risks associated with these popular supplements.

The USPSTF based its recommendations on a meta-analysis of 136 clinical trials, observational studies and a systematic review evaluating the effects of supplementation on fracture and cancer risk. It concluded that postmenopausal women should not take supplements containing less than 400 international units (IU) of vitamin D and 1,000 milligrams of calcium, noting that there is not enough evidence to evaluate the effects of taking more than those amounts. There was also insufficient data for the task force to determine whether or not healthy younger women and men of any age should take the supplements.

There's no question that "vitamin D and calcium are essential nutrients for a healthy diet," says task force member Kirsten Bibbins-Domingo, an epidemiologist and biostatistician at the University of California, San Francisco. The heart, muscles and nerves cannot work properly without the minerals, and deficiency can also cause bone loss, osteoporosis and tooth damage. Vitamin D is crucial in part because it helps the body to absorb calcium from food. In May the USPSTF recommended that people over 65 take vitamin D supplements if they have an increased risk of falls, for instance because of mobility problems or a history of falling.

But for healthy people the benefits are less clear-cut, Bibbins-Domingo says. Part of the problem is that trials involving vitamin D and calcium are inconsistent?they test different doses for varying lengths of time in diverse populations, which "makes it extra tricky when you try to put them all together and come up with a final analysis," says Erin LeBlanc, an endocrinologist at the Kaiser Permanente Center for Health Research in Portland, Ore. Earlier this week LeBlanc and her colleagues published a study online in the Journal of Women?s Health suggesting that women over 65 with higher blood vitamin D levels gain less weight over time than women with lower amounts.

Despite the difficulty of making firm conclusions about the data, some experts find the USPSTF recommendations, which are open for public comment until July 10, misleading and potentially dangerous. "I think they went too far," says Susan Ott, a bone specialist at the University of Washington School of Medicine. For one thing, "they ignored a lot of people who are getting really no calcium in their ordinary diet."

Indeed, the recommendations only apply to healthy people who are not deficient in either nutrient. (The task force did not evaluate the benefits of supplementation in people with osteoporosis, but the National Osteoporosis Foundation recommends that people with the bone disease consume at least 1,200 milligrams of calcium and 800 to 1,000 IUs of vitamin D daily through food or supplements.) Although the Institute of Medicine maintains that most Americans get enough vitamin D from food and sunlight, the organization notes that nearly 75 percent of American women between the ages of 31 and 50 do not get the recommended 1,000 milligrams of calcium from their food every day, and that a similar percentage of women older than 50 fail to consume their recommended 1,200 milligrams. (To eat 1,000 milligrams without supplementing, a person would have to eat 16 cups of cooked broccoli or drink three and a third glasses of skim milk daily.) "There are a lot of people out there who are only getting half of what we recommend," Ott says, and the USPSTF recommendations do not apply to them.

Source: http://rss.sciam.com/click.phdo?i=cbcc7b6574e978b14696d012d2579e6f

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Prepaid tuition plans flawed but still popular

CHICAGO (AP) ? Prepaid college tuition plans are no longer the surefire solution to runaway tuition costs they once seemed.

The mostly state-sponsored plans were designed as a way to save for college by locking in at least a portion of future tuition at today's prices.

The premise remains sound: Pay now to minimize the shock of rising costs. After all, tuition has increased an average 7 percent annually since 1990 and shows no sign of slowing down.

But the battered finances of state governments have raised questions about whether some plans will live up to their promises.

Numerous states have shut down their plans or changed them as their deficits widened. Facing shortfalls, some have bumped up the prices by charging substantial premiums above the cost of current tuition. And several of the 11 open plans do not offer guarantees.

"It's a model that doesn't always work," says Joseph Hurley, a CPA and the founder of Savingforcollege.com.

College financing experts advise parents and students to carefully review the specifics of their state's plan and determine if it makes sense for them.

A closer look at some important points to consider about prepaid plans:

BASICS

A prepaid tuition plan allows families to buy future tuition units or credits at current prices. If you purchase shares worth one semester's tuition when your child is young, the shares should always be worth one semester's tuition regardless of how much rates increase. The credits can sometimes also be applied to room and board.

Most prepaid plans have residency requirements. Purchased credits can be applied toward a college in another state, but there's no assurance the full cost will be covered. If a student decides to attend a private or out-of-state college, the plans typically pay the average of in-state public college tuition, according to Mark Kantrowitz, founder of the financial aid site FinAid.org.

States invest families' money in the stock market and use their investment returns to pay for the tuition.

But some programs have run into trouble after investments lost money in the market downturn in 2008-09 and tuition rose faster than expected.

Alabama had to make compromises in its program this spring in order to keep it operating, and now pays less than full tuition. Prepaid plans in Kentucky, Illinois and South Carolina are less than 80 percent funded for future payouts, raising the risk of future changes.

AVAILABLE PLANS

There are 21 prepaid plans offered in 19 states. But 10 states have closed plans to new participants.

Among the 11 open plans, only Massachusetts, Mississippi and Washington guarantee theirs with the "full faith and credit of the state," according to the College Savings Plans Network. That means they will borrow if necessary to make up the difference if the plans run short of money.

Alaska, Florida, Maryland and Virginia also back their plans with differing guarantees. Open plans in Michigan, Nevada, Illinois, Pennsylvania and Texas are backed only by the funds' assets.

Just two prepaid plans are open to residents of any state: Massachusetts' U.Plan program and the Private College 529 Plan, sponsored by the Tuition Plan Consortium representing more than 270 private colleges and universities nationwide.

PROS

Advocates of prepaid tuition plans call them "peace of mind programs" and say they still offer that comfort.

"They're still very appealing in this environment with unknown amounts of tuition increases as well as investment volatility ahead of you," says Joan Marshall, executive director of College Savings Plans of Maryland. "A couple of states clearly have had problems, but it's unfair to lump them all in together."

Prepaid plans as a whole are 93 percent funded, up from 91 percent a year ago and that's more than adequate to assure future payouts, according to the College Savings Plans Network.

As to any fears of not getting your money back, Marshall says no one who has used a prepaid plan has received a lower amount than was paid in.

Kathy and Joe Halliday of Bel Air, Md., paid off their daughter's tuition through Maryland's prepaid plan by the time she was in middle school. That meant they didn't agonize when the stock market crumbled. The plan covered Leah's two years in community college and now will take care of her tuition at Johns Hopkins University.

"It was a great relief," Kathy says. "It was the best financial investment we ever made."

Mat Forrest and his wife Jillian of West Palm Beach, Fla., recently purchased a Florida prepaid college plan for their daughter Addison, who turns 2 in August. He acknowledges that the interest rate is small and they might well do better investing the money in a stock plan. But he likes the simplicity of being locked into a fixed monthly payment of $287.71 and knowing that should take care of Addison's college tuition.

"Any time you can lock in the cost 18 years before you need to pay it, that's probably a good thing," he says. "And I don't need to stress out over the markets."

CONS

Some experts who once recommended the plans for new investors no longer do. They cite the increased risk that states won't make good on their original commitments and the chance that parents will have to pay more to make up for shortfalls in state funds.

"Peace of mind may be a fiction," says Kantrowitz. "If you're investing now for the first time, the money may disappear by the time your child is ready for college."

While losing your money is unlikely, there's a real chance of seeing your investment stay flat or even decline in value if the state makes changes that dilute the plan.

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Government Seized Car Auctions ? 5 Key Tips to Getting Your ...

You really need to consider government seized car auctions if you want to buy a quality car on a tight budget. Quite frankly, even second hand car dealerships cannot offer you a better deal than the auctions. There is always a middle man fee that used car dealers would have to charge for profits and their service. On the other hand, the government is only concerned about selling away the repossessed or seized cars without making a profit. This opens a door of opportunity for anyone to drive home a quality car at very low prices. Buying Cars at Government Seized Car Auctions Carry Some Risk

I would be bluffing you if I told you it is a bed of roses to buy cars at such auctions. Naturally, there are risks involved in bidding at auctions. But with some key tips which I am going to mention, you would be in a much better position to get a quality car for a price much lower than what it is worth. 1. Check the title of the automobile. If it is a rebuilt, take at least 30% off its value. 2. Do a vehicle history report. Compare the odometer reading against your report mileage reading. There is a physical method to do so. You can always check the brake pedals to see if the wear and tear is excessive. If the condition is very worn out and does not seem to tally with what the odometer is showing, then there is a high chance that the car?s odometer has been tampered with to show a low mileage. 3. Deduct the value if the car has exceeded the average mileage. There is a standard for the annual mileage of vehicles. According to the US Department of Transportation, on annual average, a car is driven for 13,500 miles. If the car you are interested in bidding has crossed the average, say by 1000 miles, take this figure and multiply it by 15 cents per mile exceeded. This is the value you should deduct. In this case, it is $150. 4. Gain some experience and get yourself familiar with the entire bidding process at the government seized car auctions. You may want to attend a few to understand how the process works before you actually bid for a car at the auction. It can be overwhelming for a first-time owner. 5. Trust your instinct and think logically. If a car looks really good and there is no way it could be priced so low, then there is a high probability that something is wrong with it. Avoid bidding for it even if you love it. Believe your logical mind. Simply following these 5 key tips can save you a whole lot of headaches later and get you a better idea of how to bid for the right wheels at the auto auctions. Finally, take action and check out where is the upcoming or existing government seized car auctions in your neighborhood through my car blog. Davion is crazy about fast cars. Uncover useful tips on seized car auctions such as where to find cheap seized car auctions near your home at his wildly successful car blog. Also, read another of his popular article on seized car auctions tips.

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Try It For Yourself With The Help Of These Redecorating ...

Posted on 28 May 2012. Tags: home improvement

To keep up with your personal likes and technological innovation, you need to take time from time to time to start out on brand new home improvement projects. You could potentially pay out somebody else to achieve this, but it is probable for you to successfully complete a lot of tasks all on your own. Comply with this article?s ideas.
A lot of money of metallic wool is a wonderful way to seal up a mouse opening. Rodents cannot chew steel wool like they are able to other stuff it is going to avoid far more mice from coming in.
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Try a new mailbox for some effortless home improvement. A whole new mailbox may add curb appeal to your home. Do check your local rules on necessary range from your road to ensure you do not have to adopt it downward later on. This would only take a number of hours, producing for any fast project.
If you are searching for a great way to provide your home?s walls a deal with daily life, consider using paneling. This is a fast and fairly low-cost strategy to make your house appearance brand new. When you decide that you simply do nothing like the design of the panels, you can remove them with minimal harm.
Improving your house to your wants is entirely possible. There are numerous property contractors that you can retain the services of, even though initially ensure that the venture is not something that you can deal with by yourself. Implement the advice that you?ve just figured out for your own reconstruction venture.

Should you crave additional points on gas fireplace insert take a look at Katie Q. Fedorko?s site there is loads of information not detailed on this page, visit Author?s blog to discover extra details.

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Home health companies - HEALTH, BEAUTY & FITNESS

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Learn Violin with Esteemed Violin Music Experts

Learning violin from a professional is not only a source of great entertainment and enjoyment but also a matter of great pride. Although many people think that violin music lessons can be really tough and intimidating, they need not necessarily have to be that way. Learning violin music can be easily accomplished by following a well planned and organized course. The course requires a good foundation and once that foundation is established, an individual can hope to learn the violin course in few days and with perfect professionalism and expertise. It is necessary for every learner to understand the basics of violin music lessons thoroughly and move ahead to the subsequent levels.

Violin teachers Seattle is a team of experts and professional mentors who teach and guide numerous individuals the basics of violin. Once these individuals become adept at the basics, they move ahead and take the advanced courses with them.

Learning violin may be difficult without any expert?s help and as such violin teachers Seattle are doing a tremendous job in building the right foundation for their numerous students. Many students go to learn violin every year from them because this will not only develop a unique talent in them but can also shape their career.

Similar violin courses are also held by a group of violin teachers Charlotte. These experts in this area have been teaching violin to a number of students who come from various parts to learn basics as well as advanced violin skills. These people take the entire responsibility of unearthing the hidden potential from every individual and laying the strong foundation in every student. The teaching methodology adopted by violin teachers Charlotte is exceptional and one of its kind. They are a master in their field and strive to develop the same excellence in every student.

People in Mesa looking to become expert in the music can go for the violin classes. These violin classes are run by an expert and professional group of violin teachers Mesa who are the masters of teaching this course to their numerous students. These people have been enlightening the vision and nurturing the talent of hundreds of individuals every year. Any person who is looking to get the basic understanding of violin seeks the guidance of violin teachers Mesa. Really these are true experts that have shaped the career of many individuals.

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Microsoft: No more Aero for Windows 8 | Muslim Gaming Community ...

For those that still?weren?t?aware, Windows 8 is not too far away now. For any of you that were around for Windows ME, you know the disaster that can happen when a new windows launches. Windows 7 was\is pretty good, from what I have seen from Windows 8, Im not looking forward to it and dont see the need to upgrade. Especially after this latest?announcement.

If it aint broke, dont fix it right? Well according to Microsoft, the UI was a little broken? So they have decided to take away the Aero interface that was intoroduced in Windows Vista and and replace it with?pretty much nothing. The?changes?are in fact that they will be??flattening surfaces, removing reflections, and scaling back distracting gradients.?

On the?Microsoft?blog where htey announced these changes, they went down through memory lane and posted all the interaces from the early days of windows right through to the current day interface we all know so well. I really am not sure why they are trying to make Windows 8 a tablet.. I guess we will have to wait and see if its what people want..

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